Although the physician has attempted to understand the relationship of yellow jaundice to newborn infants for a long time, and new questions about old data which force us to recognize and reevaluate our understanding of hyperbilirubinemia, the development of kernicterus, and therapies utilize. Factors that must be considered are the physiologic mechanism by which bilirubin is catabolized and excreted; the physiologic and pathologic factors that affect the catabolism and distribution of bilirubin, the mechanism by which central nervous system bilirubin toxicity occurs that is, bilirubin encephalopathy and kernicterus.
Present study was carried out to determined the factor which influenced to increased -the serum bilirubin level in both full term and pre-term infants.
Of 376 newborn infants in Korea University Hospital in the period of ten months from
March 1 to December 30, 1980. 304 full term newborn infants and 72 preterm infants were
available for the study of serum bilirubin level at the third and sixth day of the birth. The following are results analized:
1. The mean value of serum bilirubin level estimated was 10.6 mg%. The incidence of neonatal jaundice was estimated as 90.4%.
.2. The premature infants revealed are marked elevation of serum bilirubin level. Condition with increased level of serum bilirubin in variable degree include vaccum extraction and/or forcep delivery, high or low hematocrit value, low Apgar score, artificial resuscitation, cephalhematoma, and spontaneous premature rupture of the membrane.
3. There were no relationship in serum bilirubin levels between differences in sex, birth weight, number of pregnancies and ABO blood group of mother and infant.
.4. In prematurity, there were no significant difference in birth weight, gestational age, sex, Apgar score, incidence of hypoglycemia, hypothermia, convulsion, anemia and infection between hyperbilirubinemic infants and non-hyperbilirubinemic infants. Serum albumin value were significantly lower, and acidosis were seen more often in hyperbilirubinemic infants than in non.
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